anti-RRP8 antibody

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  • Alternative name

    KIAA0409, NML antibody

  • Catalog
    A007501
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman,Mouse ,Rat
  • Applications Tested/SuitableELISA,WB,IF,IHC
  • PurificationImmunogen affinity purified
  • Immunogenribosomal RNA processing 8, methyltransferase, homolog (yeast)
  • IHCImmunohistochemistry of paraffin-embedded human skin using A007501(RRP8 antibody) at dilution of 1:100
  • Western Blothuman brain tissue were subjected to SDS PAGE followed by western blot with A007501(RRP8 antibody) at dilution of 1:1500
  • Recommended dilutionWB : 1:500-1:5000
  • Product Description specificalEssential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
  • Gene nameRRP8
  • Uniprot IDO43159
  • Observed M.W.51 kDa


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