In 1975, the medical scientist E.A.Carswell et al. Found a substance in the laboratory of the United States that called "Tumor Necrosis Factor", or "TNF", "a substance that causes hemorrhagic necrosis of multiple tumors."
In 1985, Shalaby, a scientist who continued to study the subject, named TNF "TNF-α" in the immune system: "macrophages", and "lymphotoxin", which is secreted by "T lymphocytes" ) Named "TNF-β".
"TNF-α" and "TNF-β" are two "tumor necrosis factor".
Tumor necrosis factor-α (TNF-α) can directly kill tumor cells and no significant damage to normal cells, is by far the direct killing of cancer, one of the strongest biological activity factor. 80s of last century, Europe, the United States competing research, hoping to be manufactured by the artificial application of clinical, but because of serious side effects and forced to terminate.
However, the antitumor activity of TNF-α makes the researchers obsessed and reluctant to give up. Through the further study of TNF-α, to overcome its serious side effects, developed a number of highly efficient, low toxicity of TNF-α variant. Therefore, the end of the century, the medical profession to re-confirm the important position of TNF-α anti-tumor.
There have been drugs called "tumor necrosis factor" for the treatment of critically ill patients, but with serious adverse reactions: intravenous injection may be high fever, may be associated with hypotension; may occur in the same symptoms of influenza, such as chills, joints and Whole body pain, etc .; also may occur nausea, vomiting, diarrhea, platelets and leukopenia ... ... withdrawal, these symptoms quickly subsided.
Recently, many scientists at home and abroad have reported that some TNF mutants have been constructed, and their anti-tumor activity is enhanced and the side effects are reduced, providing a new way for clinical application of TNF. The medical community believes that in the near future, people will be able to get some ideal TNF mutations and for clinical ...
For the layman, the simple version of tumor necrosis factor, outlined below
Human and animal body will produce a natural "direct kill tumor cells" immune substances;
This is a "can make a variety of tumor hemorrhagic necrosis" of the material;
This immune substance is named "tumor necrosis factor";
Medical scientists imagine, to create a "tumor necrosis factor" used in patients, you can cure cancer;
But the exogenous "tumor necrosis factor" has serious side effects, clinical trials have serious adverse reactions;
Medical scientists are working hard to develop, hope in the near future, the "tumor necrosis factor" mutant for clinical ... ...
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