The drug functions like a smart thermostat for the body:
Step 1: Receptor proteins (from mRNA①) bind to specific "humoral factors" (e.g., inflammatory markers).
Step 2: Upon detection, regulator proteins (from mRNA②) activate translation of the therapeutic mRNA③.
Step 3: Therapeutic proteins (e.g., anti-inflammatory agents) are produced on demand, minimizing off-target effects 13.
"It listens to the body’s voice—producing treatment only when needed, just as a thermostat heats only when the room is cold." — Research Team 3
In critical tests, the system:
Selectively activated anti-inflammatory protein synthesis only when prostaglandin E2 (inflammation signal) was detected.
Suppressed inflammatory responses without manual intervention, proving its context-aware capability 13.
| Traditional Drugs | Smart mRNA Drug |
|---|---|
| Fixed dosing regardless of patient state | Dynamic output adjusted to real-time needs |
| Risk of underdosing/overdosing | Minimized side effects via precise biofeedback |
| Limited adaptability in chronic diseases | Ideal for fluctuating conditions (e.g., autoimmune disorders) 13 |
Chronic Diseases: Diabetes, arthritis—where biomarker levels vary daily.
Vaccines: Enable on-demand immune response modulation (e.g., boosting efficacy during infection peaks).
Drug Discovery: Serves as a "key" to decode disease mechanisms by mapping biological signal responses 13.
This innovation marks the first integration of disease-sensing and self-regulating functions into a single drug, transitioning mRNA therapy from "passive delivery" to active bio-responsive intelligence. It accelerates cross-disciplinary fusion of biology, medicine, and bioengineering for next-gen treatments