Recently, from Georgia state university and tufts university researchers by in vitro culture and animal model system for the study found that folic acid can stimulate stem Cell proliferation, which does not rely on it as the role of vitamin, related research published in international journal Developmental Cell.
Folic acid, regardless of its complement of B vitamins or from the natural folic acid in food, its normal function for all cells in the body of the play is very necessary, and to prevent neonatal development defect is critical.
Article, the researchers found that for the first time, adult stem cell population can be a kind of come from the animal body external factors, namely the folic acid from bacteria to control, such as c. elegans nematode model.
Researcher Edward Kipreos says our research shows that the reproductive stem cells in the body of the elegans are divided by folic acid from the bacteria diet.
Folic acid is a kind of essential B vitamins, but the researchers found that folic acid special ability to stimulate the reproductive cells may not be dependent on it as the role of B vitamins, which suggests that folic acid may be directly as a signal molecule to play a role.
Naturally occurring folate tend to exist in many chemical forms, such as folic acid in food or with metabolic activity in the human body in the form of folic acid, etc., at the same time in fortified foods and supplements of folic acid is also in a major initiative form.
Folic acid was found in 1945, starting from the date of discovery, on a lot of work on it, many researchers now and folic acid related research has more than 50000 papers, and in this paper, we study a special, because the research reveals that the new role of folic acid, rather than previous research highlights the role of folic acid.
The grain in the United States and other countries have folic acid is added, and folic acid supplementation can significantly help to reduce neural tube birth defects of babies born, however, don't rely on the role of vitamin folic acid may can help provide a secondary path, to affect the human body.
In the article, the researchers found that a particular folate receptor called folr-1 is essential for stimulating the growth of reproductive stem cells in the body of the elegans.
At the same time, the researchers also observed in c. elegans airframe FOLR - 1 receptors promote the process of germ cell tumors, perhaps and folate receptor stimulation in the human body special cancer similar to the progress of the process.
Of course, the beta receptor may not be necessary to transport folic acid to cells as a vitamin, but it can stimulate cell division.
Finally, the researchers say the study may also provide a new tool to help study the main genetic model organisms.
Reference:
Bacterial Folates Provide an Exogenous Signal for C. elegans Germline Stem Cell Proliferation
doi:10.1016/j.devcel.2016.06.013
Snehal N. Chaudhari4, Madhumati Mukherjee4, Alexandra S. Vagasi, Gaofeng Bi, Mohammad M. Rahman5, Christine Q. Nguyen, Ligi Paul, Jacob Selhub, Edward T. Kipreos
Here we describe an in vitro primary culture system for Caenorhabditis elegans germline stem cells. This culture system was used to identify a bacterial folate as a positive regulator of germ cell proliferation. Folates are a family of B-complex vitamins that function in one-carbon metabolism to allow the de novo synthesis of amino acids and nucleosides. We show that germ cell proliferation is stimulated by the folate 10-formyl-tetrahydrofolate-Glun both in vitro and in animals. Other folates that can act as vitamins to rescue folate deficiency lack this germ cell stimulatory activity. The bacterial folate precursor dihydropteroate also promotes germ cell proliferation in vitro and in vivo, despite its inability to promote one-carbon metabolism. The folate receptor homolog FOLR-1 is required for the stimulation of germ cells by 10-formyl-tetrahydrofolate-Glun and dihydropteroate. This work defines a folate and folate-related compound as exogenous signals to modulate germ cell proliferation.
prev:How to prepare acute hippocampal tablets of rats(2017-08-25)
next:How can I improve PCR and get better access to the end band?(2017-08-28)