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Alternative name
FLJ43106, LAM, TSC2, TSC4, Tuberin, tuberous sclerosis 2, Tuberous sclerosis 2 protein antibody
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Catalog
A009101
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IF,IHC
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PurificationImmunogen affinity purified
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Immunogentuberous sclerosis 2
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IHCImmunohistochemistry of paraffin-embedded human kidney slide using A009101( TSC2-Specific Antibody) at dilution of 1:50
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Western Blotmouse lung tissue were subjected to SDS PAGE followed by western blot with A009101(TSC2-Specific antibody) at dilution of 1:300
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Recommended dilutionWB:1:200-1:2000;IHC:1:20-1:200；IF:1:10-1:100
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Product Description specificalTSC2, also named as TSC4, FLJ43106 and LAM, acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In complex with TSC1, TSC2 inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. TSC2 implicated as a tumor suppressor. It is involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. TSC2 stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors. The antibody is specific to TSC2.
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Gene nameTSC2
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locationCytoplasm,Membrane
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Uniprot IDP49815
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Calculated M.W.190kDa
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Observed M.W.170-180 kDa
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