anti-Acetylated tubulin (Lys40) antibody

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  • Alternative name

    Acetylated alpha tubulin, Acetylated tubulin, acetylated-a-tubulin, acetyl-a-tubulin, alpha tubulin, Alpha tubulin 3, tubulin,TUBA1A antibody

  • Catalog
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityMonoclonal Antibody
  • Host Mouse
  • Species ReactivityHuman, Mouse ,Rat,Dog
  • Applications Tested/SuitableELISA,WB,IHC,IF
  • PurificationProtein A+G purification
  • Immunogentubulin, alpha 1a
  • IHChuman lung cancer tissue slide using A000082( TUBA1A(ace-40Lys) Antibody) at dilution of 1:50
  • Western BlotL02 cells were subjected to SDS PAGE followed by western blot with A000082( TUBA1A(ace-40Lys) Antibody) at dilution of 1:1000
  • Recommended dilutionWB :1:500-1:5000;IF:1:20-1:200;IHC:1:20-1:200
  • Product Description specificalTubulin, composed of heterodimers of alpha and beta tubulin, is the mainly component of microtubules which play important roles in cell motility, mitosis, and intracellular vesicle transport. Both alpha and beta tubulin undergo several posttranslational modifications such as polyglutamylation and acetylation/deacetylation. Tubulin acetylation occurs on lysine-40 at the N-terminal of alpha tubulin and is conserved across species. The histone deacetylase HDAC6 and SIRT2 has been identified as tubulin deacetylases. Reversible acetylation of alpha tubulin may be implicated in regulating microtubule stability, cell motility, and axon regeneration. The level of acetylated tubulin has been linked to epithelial malignancies and sensitivity to chemotherapy. In addition, acetylated tubulin has been widely used as a marker for primary cilia. This antibody is specific to the acetylated tubulin; it does not recognize non-acetylated tubulin.
  • locationCytoplasm,Cytoskeleton,Microtubule
  • Uniprot IDQ71U36
  • Calculated M.W.52kDa

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