-
Alternative name
IGKJRB, IGKJRB1, RBPJK, RBPSUH antibody
-
Catalog
A007195
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman, Mouse
-
Applications Tested/SuitableELISA,WB,IHC,IP
-
PurificationImmunogen affinity purified
-
Immunogenrecombination signal binding protein for immunoglobulin kappa J region
-
IHCImmunohistochemistry of paraffin-embedded human pancreas cancer using A007195(RBPJ antibody) at dilution of 1:100
-
Western Blotmouse kidney tissue were subjected to SDS PAGE followed by western blot with A007195(RBPJ antibody) at dilution of 1:1000
-
Recommended dilutionWB : 1:500-1:5000
-
Product Description specificalTranscriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788).
-
Gene nameRBPJ
-
Uniprot IDQ06330
-
Observed M.W.60 kDa
-