anti-WNK4 antibody

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  • Alternative name

    PHA2B, PRKWNK4, WNK4 antibody

  • Catalog
    A009516
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman
  • Applications Tested/SuitableELISA,WB
  • PurificationImmunogen affinity purified
  • ImmunogenWNK lysine deficient protein kinase 4
  • Western Blotmouse colon tissue were subjected to SDS PAGE followed by western blot with A009516( WNK4 Antibody) at dilution of 1:600
  • Recommended dilutionWB : 1:200-1:2000
  • Product Description specificalSerine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).
  • Gene nameWNK4
  • locationCell junction,Tight junction
  • Uniprot IDQ96J92
  • Calculated M.W.135kDa,Observed 73kDa
  • Observed M.W.70 kDa


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