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Alternative name
EST01027, HHCPA78, THIF, Thioredoxin binding protein 2, TXNIP, VDUP1 antibody
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Catalog
A009129
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,IHC,WB,IF
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PurificationImmunogen affinity purified
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Immunogenthioredoxin interacting protein
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IHCImmunohistochemistry of paraffin-embedded human kidney tissue slide using A009129( TXNIP Antibody) at dilution of 1:200
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Western BlotK-562 cells were subjected to SDS PAGE followed by western blot with A009129( TXNIP Antibody) at dilution of 1:600
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Recommended dilutionWB:1:200-1:2000;IP:1:200-1:2000;IHC:1:50-1:500;IF:1:10-1:100
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Product Description specificalMay act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
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Gene nameTXNIP
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locationCytoplasm
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Uniprot IDQ9H3M7
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Calculated M.W.50kDa
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Observed M.W.50 kDa
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