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Alternative name
C20orf97, NIPK, SINK, SKIP3, TRB 3, TRB3, TRIB3, Tribbles homolog 3 antibody
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Catalog
A008966
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IP
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PurificationImmunogen affinity purified
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Immunogentribbles homolog 3 (Drosophila)
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Western Blotmouse liver tissue were subjected to SDS PAGE followed by western blot with A008966(TRIB3 antibody) at dilution of 1:600
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Recommended dilutionWB:1:500-1:5000;IP:1:200-1:2000
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Product Description specificalDisrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.
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Gene nameTRIB3
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locationNucleus
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Uniprot IDQ96RU7
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Calculated M.W.40kDa,observed 45-65kDa
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Observed M.W.40-45 kDa
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