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Alternative name
CED, DPD1, LAP, TGF beta 1, TGFB, TGFB1, TGFbeta, TGF-beta1, TGF-β1 antibody
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Catalog
A008638
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,IHC
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PurificationImmunogen affinity purified
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Immunogentransforming growth factor, beta 1
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IHCImmunohistochemistry of paraffin-embedded
human breast cancer tissue slide using
A008638( TGFB1 Antibody) at dilution of 1:200
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Western BlotMCF-7 cells were subjected to SDS PAGE followed by western blot with A008638( TGFB1 Antibody) at dilution of 1:600
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Recommended dilutionWB:1:200-1:2000;IHC:1:50-1:500
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Product Description specificalTGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease (CED) which known as progressive diaphyseal dysplasia 1 (DPD1).
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Gene nameTGFB1
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Uniprot IDP01137
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Calculated M.W.44kDa,observed 25kDa
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Observed M.W.25 kDa
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