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Alternative name
ARHGAP34, FNBP2, Formin binding protein 2, KIAA0456, SRGAP2, srGAP3 antibody
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Catalog
A008225
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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ImmunogenSLIT-ROBO Rho GTPase activating protein 2
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IHCImmunohistochemistry of paraffin-embedded human kidney slide using A008225( SRGAP2 Antibody) at dilution of 1:50
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Western Blotmouse kidney tissue were subjected to SDS PAGE followed by western blot with A008225(SRGAP2 antibody) at dilution of 1:1000
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Recommended dilutionWB : 1:500-1:5000
IP : 1:500-1:5000
IHC : 1:20-1:200
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Product Description specificalRAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.
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Gene nameSRGAP2
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Uniprot IDO75044
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Calculated M.W.121 kDa
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Observed M.W.121 kDa
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