-
Alternative name
CHAP1, CHAP1/DSK2, Dsk2, DSK2 homolog, hPLIC 2, HRIHFB2157, LIC 2, N4BP4, PLIC 2, PLIC2, RIHFB2157, ubiquilin 2, Ubiquilin-2, UBQLN2 antibody
-
Catalog
A009205
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman,Rat
-
Applications Tested/SuitableELISA,WB,IHC,IF
-
PurificationImmunogen affinity purified
-
Immunogenubiquilin 2
-
IHCImmunohistochemistry of paraffin-embedded human testis slide using A009205( UBQLN2 Antibody) at dilution of 1:50
-
Western Blotrat brain tissue were subjected to SDS PAGE followed by western blot with A009205(UBQLN2 antibody) at dilution of 1:800
-
Recommended dilutionWB : 1:200-1:2000;IHC:1:20-1:200；IF：1:20-1:200
-
Product Description specificalPlays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and the endoplasmic reticulum- associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor- arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683).
-
Gene nameUBQLN2
-
locationCytoplasm,Cytoplasmic vesicle,Membrane,Nucleus
-
Uniprot IDQ9UHD9
-
Calculated M.W.70kDa
-
Observed M.W.66-70 kDa
-