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Alternative name
cul nedd8, FLJ43224, Nedd 8, NEDD8, Neddylin, Ubiquitin like protein Nedd8 antibody
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Catalog
A005647
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenneural precursor cell expressed, developmentally down-regulated 8
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IHCImmunohistochemistry of paraffin-embedded human colon cancer tissue slide using A005647( NEDD8 Antibody) at dilution of 1:50
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Western Blotmouse brain tissue were subjected to SDS PAGE followed by western blot with A005647(NEDD8 antibody) at dilution of 1:800
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalUbiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
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Gene nameNEDD8
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Uniprot IDQ15843
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Observed M.W.6-10 kDa
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