StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Species ReactivityHuman,Mouse ,Rat, Monkey
PurificationImmunogen affinity purified
ImmunogenHtrA serine peptidase 2
IHCImmunohistochemistry of paraffin-embedded human kidney using A004070(HTRA2 antibody) at dilution of 1:100
Western BlotHEK-293 cells were subjected to SDS PAGE followed by western blot with A004070(HTRA2 antibody) at dilution of 1:2000
Recommended dilutionWB : 1:1000-1:10000
Product Description specificalSerine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.