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Alternative name
3 beta HSD VII, C(27) 3 beta HSD, HSD3B7, PFIC4, SDR11E3 antibody
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Catalog
A004032
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenhydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
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IHCImmunohistochemistry of paraffin-embedded human pancreas cancer using A004032(HSD3B7 antibody) at dilution of 1:50
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Western Blotmouse liver tissue were subjected to SDS PAGE followed by western blot with A004032(HSD3B7 antibody) at dilution of 1:500
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalThe 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7- alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein- coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.
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Gene nameHSD3B7
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Uniprot IDQ9H2F3
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Observed M.W.36 kDa
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