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Alternative name
Angiopoietin like 4, Angiopoietin like protein 4, Angiopoietin related protein 4, ANGPTL2, ANGPTL4, ARP4, FIAF, HFARP, NL2, PGAR, pp1158, PSEC0166, UNQ171/PRO197 antibody
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Catalog
A000399
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,IHC,IF,IP,WB
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PurificationImmunogen affinity purified
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Immunogenangiopoietin-like 4
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IHCImmunohistochemistry of paraffin-embedded human kidney slide using A000399( ANGPTL4 Antibody) at dilution of 1:50
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Western BlotHEK-293 cells were subjected to SDS PAGE followed by western blot with A000399( ANGPTL4 Antibody) at dilution of 1:600
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Recommended dilutionWB :1:200-1:2000;IHC:1:20-1:200;IF:1:20-1:200;IP:1:200-1:2000
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Product Description specificalProtein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).
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Gene nameANGPTL4
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locationExtracellular matrix,Secreted
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Uniprot IDQ9BY76
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Calculated M.W.45kDa
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Observed M.W.45-50 kDa
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