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Alternative name
CACH1, CACN1, CACNL1A3 antibody
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Catalog
A001173
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogencalcium channel, voltage-dependent, L type, alpha 1S subunit
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IHCImmunohistochemistry of paraffin-embedded human skeletal muscle slide using A001173( CACNA1S Antibody) at dilution of 1:50
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Western Blothuman brain tissue were subjected to SDS PAGE followed by western blot with A001173(CACNA1S antibody) at dilution of 1:1000
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalVoltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
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Gene nameCACNA1S
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Uniprot IDQ13698
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Observed M.W.200-220kd
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