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Alternative name
4E BP2, 4EBP2, eIF4E binding protein 2, EIF4EBP2, PHASII antibody
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Catalog
A002723
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,IHC,WB
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PurificationImmunogen affinity purified
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Immunogeneukaryotic translation initiation factor 4E binding protein 2
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IHCImmunohistochemistry of paraffin-embedded human prostate cancer using A002723(EIF4EBP2 antibody) at dilution of 1:100
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Western Blotmouse testis tissue were subjected to SDS PAGE followed by western blot with A002723( EIF4EBP2 Antibody) at dilution of 1:300
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Recommended dilutionWB : 1:200-1:1000
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Product Description specificalRepressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).
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Gene nameEIF4EBP2
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Uniprot IDQ13542
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Observed M.W.~20 kDa
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