StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Species ReactivityHuman,Mouse ,Rat
PurificationImmunogen affinity purified
Immunogentectonic family member 1
IHCImmunohistochemistry of paraffin-embedded human kidney tissue slide using A008567( TCTN1 Antibody) at dilution of 1:50
Western Blotmouse embryo tissue were subjected to SDS PAGE followed by western blot with A008567(TCTN1 antibody) at dilution of 1:800
Recommended dilutionWB : 1:500-1:5000
Product Description specificalComponent of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23 (By similarity).