anti-CSK antibody

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  • Alternative name

    C Src kinase, c src tyrosine kinase, CSK, Protein tyrosine kinase CYL, Tyrosine protein kinase CSK antibody

  • Catalog
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman
  • Applications Tested/SuitableELISA,WB,IHC,IF,IP
  • PurificationImmunogen affinity purified
  • Immunogenc-src tyrosine kinase
  • IHCImmunohistochemistry of paraffin-embedded human lung using A002016(CSK antibody) at dilution of 1:200
  • Western BlotHL-60 cells were subjected to SDS PAGE followed by western blot with A002016(CSK antibody) at dilution of 1:800
  • Recommended dilutionWB : 1:200-1:2000
  • Product Description specificalNon-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
  • Gene nameCSK
  • Uniprot IDP41240
  • Observed M.W.50 kDa

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