anti-WTAP antibody

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  • Alternative name

    DKFZp686F20131, Female lethal(2)D homolog, hFL(2)D, KIAA0105, WT1 associated protein, WTAP antibody

  • Catalog
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityMonoclonal Antibody
  • Host Mouse
  • Species ReactivityHuman, Mouse
  • Applications Tested/SuitableELISA,WB,IHC
  • PurificationProtein A+G purification
  • ImmunogenWilms tumor 1 associated protein
  • IHCImmunohistochemistry of paraffin-embedded human cervical cancer using A009530(WTAP antibody) at dilution of 1:50
  • Western BlotHEK-293 cells were subjected to SDS PAGE followed by western blot with A009530( WTAP Antibody) at dilution of 1:2000
  • Recommended dilutionWB:1:1000-1:10000;IF:1:20-1:200;IHC:1:20-1:200
  • Product Description specificalRegulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle (PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator (PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes (PubMed:17095724).
  • Gene nameWTAP
  • locationNucleus
  • Uniprot IDQ15007
  • Calculated M.W.49kDa
  • Observed M.W.50-55 kDa

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