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Alternative name
KIAA0683 antibody
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Catalog
A008592
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityMonoclonal Antibody
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Host Mouse
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Species ReactivityHuman
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Applications Tested/SuitableELISA,IHC,IF,IP,WB
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PurificationProtein A+G purification
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ImmunogenTEL2, telomere maintenance 2, homolog (S. cerevisiae)
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IHCImmunohistochemistry of paraffin-embedded human kidney tissue slide using A008592( TELO2 Antibody) at dilution of 1:200
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Western BlotA431 cells were subjected to SDS PAGE followed by western blot with A008592(TELO2 antibody) at dilution of 1:500
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalRegulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation.
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Gene nameTELO2
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Uniprot IDQ9Y4R8
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Observed M.W.92 kDa
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