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Alternative name
CIR2, SPUF antibody
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Catalog
A005661
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityMonoclonal Antibody
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Host Mouse
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,IHC,WB
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PurificationProtein A+G purification
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Immunogenneuron derived neurotrophic factor
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IHCImmunohistochemistry of paraffin-embedded human cerebellum using A005661(NENF antibody) at dilution of 1:50
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Western Blothuman brain tissue were subjected to SDS PAGE followed by western blot with A005661(NENF antibody) at dilution of 1:1000
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalActs as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis (PubMed:22748190).
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Gene nameNENF
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Uniprot IDQ9UMX5
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Observed M.W.18 kDa
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