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Alternative name
PRSS15 antibody
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Catalog
A004821
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityMonoclonal Antibody
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Host Mouse
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IF
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PurificationProtein A+G purification
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Immunogenlon peptidase 1, mitochondrial
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IHCImmunohistochemistry of paraffin-embedded human lung cancer tissue slide using A004821( LONP1 Antibody) at dilution of 1:800 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
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Western BlotJurkat cells were subjected to SDS PAGE followed by western blot with A004821( LONP1 Antibody) at dilution of 1:5000
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single- stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site- specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein.
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Gene nameLONP1
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Uniprot IDP36776
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Observed M.W.100 kDa
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