anti-Alpha-1-Antitrypsin antibody

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  • Alternative name

    A1A, A1AT, AAT, Alpha 1 antiproteinase, Alpha 1 antitrypsin, Alpha 1 protease inhibitor, PI, PI1, PRO2209, PRO2275, Serpin A1, SERPINA1, SPAAT, α1-antitrypsin antibody

  • Catalog
    A000338
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityMonoclonal Antibody
  • Host Mouse
  • Species ReactivityHuman
  • Applications Tested/SuitableELISA,WB,IHC,IF
  • PurificationProtein A+G purification
  • Immunogenserpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
  • IHCImmunohistochemistry of paraffin-embedded human liver using A000338(Alpha-1-Antitrypsin antibody) at dilution of 1:50
  • Western BlotHepG2 cells were subjected to SDS PAGE followed by western blot with A000338(Alpha-1-Antitrypsin antibody) at dilution of 1:1000
  • Recommended dilutionWB :1:500-1:5000;IP:1:500-1:5000;IF:1:20-1:200;IHC:1:20-1:200
  • Product Description specificalSERPINA1 is the gene for a protein called alpha-1-antitrypsin (AAT), which is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. AAT is a glycoprotein synthesized primarily by hepatocytes, with smaller amountssynthesized by intestinal epithelial cells, neutrophils, pulmonary alveolar cells and macrophages. AAT is the most abundant, endogenous serine protease inhibitor in blood circulation and it has been implicated in regulating vital fluid phase biological events such as blood coagulation, fibrinolysis, complement activation, apoptosis, reproduction, tumor progression and inflammatory response. The primary function of AAT is thought to be the inactivation of neutrophil elastase and other endogenous serine proteases. Defects in SERPINA1 can cause emphysema or liver disease.
  • Gene nameSERPINA1
  • locationEndoplasmic reticulum,Extracellular matrix,Secreted
  • Uniprot IDP01009
  • Calculated M.W.50kDa
  • Observed M.W.40 kDa,45-53 kDa




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