anti-ALK,CD246 antibody

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  • Alternative name

    ALK, ALK tyrosine kinase receptor, ALK,CD246, Anaplastic lymphoma kinase, CD246, TFG/ALK antibody

  • Catalog
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityMonoclonal Antibody
  • Host Mouse
  • Species ReactivityHuman
  • Applications Tested/SuitableELISA,IHC,WB
  • PurificationProtein A+G purification
  • Immunogenanaplastic lymphoma receptor tyrosine kinase
  • IHCImmunohistochemistry of paraffin-embedded human lymphoma slide using A000310( ALK,CD246 Antibody) at dilution of 1:50
  • Western BlotRecombinant protein were subjected to SDS PAGE followed by western blot with A000310( ALK,CD246 Antibody) at dilution of 1:1000
  • Recommended dilutionWB :1:500-1:5000;IHC:1:20-1:200
  • Product Description specificalALK, also named as CD246, is a receptor tyrosine kinase (RTK) that belongs to the protein kinase superfamily. ALK is usually found in the nervous system and appears to play an important role in the normal development and function of the nervous system. ALK was originally identified as part of the NPM (Nucleophosmin)-ALK oncogenic fusion protein, resulting from the (2;5)(p23;q35) translocation that is frequently associated with anaplastic large-cell lymphoma (ALCL). The EML4 (echinoderm microtubule-associated protein-like 4)-ALK fusion protein have been described in non-small-cell lung cancer (NSCLC), this transforming fusion kinase is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC (PMID: 17625570).
  • Gene nameALK
  • locationCell membrane,Membrane
  • Uniprot IDQ9UM73
  • Calculated M.W.176kDa

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