anti-CD146/MCAM antibody

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  • Alternative name

    CD146, MCAM, MUC18,Cell surface glycoprotein MUC18,Cell surface glycoprotein P1H12,Melanoma cell adhesion molecule,Melanoma-associated antigen A32,Melanoma-associated antigen MUC18 antibody

  • Catalog
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityMonoclonal Antibody
  • Host Mouse
  • Species ReactivityHuman
  • Applications Tested/SuitableELISA,WB,IHC,FC
  • PurificationProtein A+G purification
  • Immunogenmelanoma cell adhesion molecule
  • IHCImmunohistochemistry of paraffin-embedded human liver cancer tissue slide using A001429( CD146, MCAM Antibody) at dilution of 1:20
  • Western BlotA375 cells were subjected to SDS PAGE followed by western blot with A001429(CD146, MCAM antibody) at dilution of 1:1000
  • Recommended dilutionWB:1:500-1:5000;IHC:1:20-1:200
  • Product Description specificalCD146, also known as melanoma cell adhesion molecule (MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein belonging to the immunoglobulin (Ig) superfamily (PMID: 8378324). Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adult tissue, CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis, and has been used as marker of circulating endothelium cells (CECs) (PMID: 19356677).
  • Gene nameMCAM
  • Uniprot IDP43121
  • Calculated M.W.72kDa,Observed 120kDa
  • Observed M.W.113-120 kDa

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