Human KARS ELISA Kit

Alternative name
Human lysyl-tRNA synthetase ELISA Kit;Human lysRS ELISA Kit;Human KIAA0070 ELISA Kit;Human CMTRIB ELISA Kit;Human DFNB89 ELISA Kit;Human KARS1 ELISA Kit;Human KARS2 ELISA Kit;Human KRS ELISA Kit;Human lysine--tRNA ligase ELISA Kit;Human lysine tRNA ligase ELISA Kit;
Catalog
E023317
species
Human
GeneKARS
SpecificityThis kit exhibits no detectable cross-reactivity with HRS, NRS, WRS, SRS, YRS, GRS and AIMP1
SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
SensitivityThe minimum detectable dose of KRS was determined by two standard deviations to the mean value of 20 blank samples. The minimum detectable dose of human KRS using a standard curve generated is 1.7 ng/ml.
Intended UseHuman KARS ELISA Kit allows for the in vitro quantitative determination of KARS , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
StorageStore the whole ELISA kit at 4℃
Product Categories/FamilyImmunology; Cytokines & Cell Signalling; Research Assays; Assay Categories
Product Description
specificalBackground: Among the components within the multi-tRNA synthetase complex (MSC), lysyltRNA synthetase (KRS) is the most functionally versatile and found at various cellular locations (1). For instance, in the nucleus of activated mast cells, KRS was shown to interact with transcriptional factors such as MITF for the induction of target genes (2). In addition, KRS can be secreted from some inflammatory cancer cells to induce proinflammatory cytokines, such as TNF-? (3). Although KRS was also identified in plasma membrane (1, 4-6), its functional implication has not been understood. KRS is translocated to plasma membrane in a laminin-dependent manner and associates with the 67-kDa laminin receptor (67LR). Lysyl-tRNA synthetase (KRS) can translocate to the nucleus to bind microphthalmia-associated transcription factor, which is an oncogenic transcriptional activator that is implicated in the development of melanoma. KRS is also secreted and induces the production of TNF from macrophages.
Human Lysine--tRNA ligase Protein information
Uniprot ID SYK_HUMAN
Uniprot AC Q15046; A8MSK1; D3DUK4; O14946; Q96J25; Q9HB23;
UniGene Hs.3100;
GeneID 3735
KEGG hsa:3735;
Human Lysine--tRNA ligase Protein SEQUENCE
SEQUENCE 597 AA; 68048 MW; E7770953332D905D CRC64;
MAAVQAAEVK VDGSEPKLSK NELKRRLKAE KKVAEKEAKQ KELSEKQLSQ
ATAAATNHTT DNGVGPEEES VDPNQYYKIR SQAIHQLKVN GEDPYPHKFH
VDISLTDFIQ KYSHLQPGDH LTDITLKVAG RIHAKRASGG KLIFYDLRGE
GVKLQVMANS RNYKSEEEFI HINNKLRRGD IIGVQGNPGK TKKGELSIIP
YEITLLSPCL HMLPHLHFGL KDKETRYRQR YLDLILNDFV RQKFIIRSKI
ITYIRSFLDE LGFLEIETPM MNIIPGGAVA KPFITYHNEL DMNLYMRIAP
ELYHKMLVVG GIDRVYEIGR QFRNEGIDLT HNPEFTTCEF YMAYADYHDL
MEITEKMVSG MVKHITGSYK VTYHPDGPEG QAYDVDFTPP FRRINMVEEL
EKALGMKLPE TNLFETEETR KILDDICVAK AVECPPPRTT ARLLDKLVGE
FLEVTCINPT FICDHPQIMS PLAKWHRSKE GLTERFELFV MKKEICNAYT
ELNDPMRQRQ LFEEQAKAKA AGDDEAMFID ENFCTALEYG LPPTAGWGMG
IDRVAMFLTD SNNIKEVLLF PAMKPEDKKE NVATTDTLES TTVGTSV
UCSC uc002feq.4; human. [Q15046-1];

Category

Human KARS ELISA Kit

Human lysyl-tRNA synthetase ELISA Kit;Human lysRS ELISA Kit;Human KIAA0070 ELISA Kit;Human CMTRIB ELISA Kit;Human DFNB89 ELISA Kit;Human KARS1 ELISA Kit;Human KARS2 ELISA Kit;Human KRS ELISA Kit;Human lysine--tRNA ligase ELISA Kit;Human lysine tRNA ligase ELISA Kit;