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Human GNRH1 ELISA Kit

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  • Alternative name

    Human Progonadoliberin I ELISA Kit;Human Gonadoliberin I ELISA Kit;Human Gonadorelin ELISA Kit;Human Gonadotropin-releasing hormone I ELISA Kit;Human GnRH-I ELISA Kit;Human luliberin I ELISA Kit;Human Luteinizing hormone-releasing hormone I ELISA Kit;Human LH-RH I ELISA Kit;Human GnRH-associated peptide I ELISA Kit;Human GNRH ELISA Kit;Human GRH ELISA Kit;Human LHRH ELISA Kit;Human LNRH ELISA Kit;Human gonadotropin releasing hormone 1 ELISA Kit;Human progonadoliberin-1 ELISA Kit;Human GnRH-associated peptide 1 ELISA Kit;Human gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) ELISA Kit;Human leuteinizing-releasing hormone ELISA Kit;Human prolactin release-inhibiting factor ELISA Kit;
  • Catalog
    E017329
  • species
    Human
  • GeneGNRH1
  • SpecificityThis assay has high sensitivity and excellent specificity for detection of Human GNRH1. No significant cross-reactivity or interference between Human GNRH1 and analogues was observed.
  • SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
  • Sensitivity0.83 pg/ml
  • Intended UseHuman GNRH1 ELISA Kit allows for the in vitro quantitative determination of GNRH1 , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
  • StorageStore the whole ELISA kit at 4℃
  • Product Description
    specifical    Introduction: Gonadotropin-releasing hormone (GnRH), also known as Luteinizing-hormone releasing hormone (LHRH) and luliberin, is a tropic peptide hormone responsible for the release of FSH and LH from the anterior pituitary. GnRH is synthesized and released from neurons within the hypothalamus. The gene, GNRH1, for the GNRH precursor is located on chromosome 8. In mammals, the linear decapeptide end product is synthesized from a 92 amino acid preprohormone in the preoptic anterior hypothalamus. GnRH is considered a neurohormone, a hormone produced in a specific neural cell and released at its neural terminal. A key area for production of GNRH is the preoptic area of the hypothalamus, that contains most of the GNRH-secreting neurons. GnRH neurons originate in the nose and migrate into the brain where they are scattered throughout the medial septum and hypothalamus and connected by very long >1 mm long dendrites. These bundle together so they receive shared synaptic input, a process that allows them to synchronize their GnRH release. GnRH is secreted in the hypophysial portal bloodstream at the median eminence. The portal blood carries the GnRH to the pituitary gland, which contains the gonadotrope cells, where GnRH activates its own receptor, gonadotropin-releasing hormone receptor (GNRHR), a seven transmembrane G-protein coupled receptor that stimulates the beta isoform of Phosphoinositide phospholipase C, which goes on to mobilize calcium and protein kinase C. This results in the activation of proteins involved in the synthesis and secretion of the gonadotropins, LH and FSH. GnRH is degraded by proteolysis within a few minutes. Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to GnRH. Standards or samples are then added to the appropriate microtiter plate wells with a Horseradish Peroxidase (HRP)-conjugated monoclonal antibody preparation specific for GnRH and incubated. Then substrate solution A and B are added to each well. Only those wells that contain GnRH, HRP-conjugated antibody will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of GnRH in the samples is then determined by comparing the O.D. of the samples to the standard curve.
  • Human GnRH-associated peptide 1 Protein information
  • Uniprot ID GON1_HUMAN
  • Uniprot AC P01148; A0AVP0;
  • UniGene Hs.82963;
  • GeneID 2796
  • KEGG hsa:2796;
  • Human GnRH-associated peptide 1 Protein SEQUENCE

  • SEQUENCE 92 AA; 10380 MW; 30A72221B076FA79 CRC64;

    MKPIQKLLAG LILLTWCVEG CSSQHWSYGL RPGGKRDAEN LIDSFQEIVK

    EVGQLAETQR FECTTHQPRS PLRDLKGALE SLIEEETGQK KI

  • UCSC uc003xem.5; human.;



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