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Alternative name
ZC3HC1, 1110054L24Rik, hNIPA, HSPC216, NIPA antibody
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Catalog
A009608
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,WB
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PurificationImmunogen affinity purified
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Immunogenzinc finger, C3HC-type containing 1
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Western Blotmouse lung tissue were subjected to SDS PAGE followed by western blot with A009608(ZC3HC1 antibody) at dilution of 1:500
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalEssential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events.
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Gene nameZC3HC1
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Uniprot IDQ86WB0
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Calculated M.W.55kDa
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Observed M.W.55kd
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