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Alternative name
ZBP1, C20orf183, DLM1, Z DNA binding protein 1, DLM 1 antibody
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Catalog
A009586
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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ImmunogenZ-DNA binding protein 1
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IHCImmunohistochemistry of paraffin-embedded human liver cancer using A009586(ZBP1 antibody) at dilution of 1:50
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Western BlotJurkat cells were subjected to SDS PAGE followed by western blot with A009586(ZBP1 antibody) at dilution of 1:400
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Recommended dilutionWB:1:500-1:5000;IHC:1:20-1:200
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Product Description specificalParticipates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
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Gene nameZBP1
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locationNucleus,ytoplasm
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Uniprot IDQ9H171
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Calculated M.W.49kDa,Observed 66kDa
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Observed M.W.68kd
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