anti-ZAK antibody

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  • Alternative name

    AZK, HCCS 4, MLK related kinase, MLK7, mlklak, MLT, MLTK, MRK, ZAK antibody

  • Catalog
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman,Mouse ,Rat
  • Applications Tested/SuitableELISA,WB,IHC,IF
  • PurificationImmunogen affinity purified
  • Immunogensterile alpha motif and leucine zipper containing kinase AZK
  • IHCImmunohistochemistry of paraffin-embedded human liver tissue slide using A009581( ZAK Antibody) at dilution of 1:50
  • Western BlotHepG2 cells were subjected to SDS PAGE followed by western blot with A009581(ZAK antibody) at dilution of 1:500
  • Recommended dilutionWB:1:500-1:5000;IHC:1:20-1:200;IF:1:10-1:100
  • Product Description specificalStress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636). _x000D_Isoform 1: Phosphorylates histone H3 at 'Ser-28' (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189).
  • Gene nameZAK
  • locationCytoplasm,Nucleus
  • Uniprot IDQ9NYL2
  • Calculated M.W.91kDa,Observed 52kDa
  • Observed M.W.55 kDa

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