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Alternative name
AIP2, WW domain containing protein 2, WWP2, WWp2 like antibody
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Catalog
A009535
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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ImmunogenWW domain containing E3 ubiquitin protein ligase 2
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IHCImmunohistochemistry of paraffin-embedded human pancreas cancer using A009535(WWP2 antibody) at dilution of 1:100
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Western Blotmouse liver tissue were subjected to SDS PAGE followed by western blot with A009535(WWP2 antibody) at dilution of 1:500
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Recommended dilutionWB:1:200-1:2000;IHC:1:20-1:200
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Product Description specificalE3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation- induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
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Gene nameWWP2
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locationNucleus
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Uniprot IDO00308
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Calculated M.W.99kDa,Observed 120kDa
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Observed M.W.110-115 kDa
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