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Alternative name
AIP5, DKFZp434D2111, hSDRP1, Tiul1, WW domain containing protein 1, WWP1 antibody
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Catalog
A009534
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IP
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PurificationImmunogen affinity purified
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ImmunogenWW domain containing E3 ubiquitin protein ligase 1
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Western BlotPC-3 cells were subjected to SDS PAGE followed by western blot with A009534(WWP1 antibody) at dilution of 1:300
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Recommended dilutionWB:1:200-1:2000;IP:1:200-1:1000;IF:1:20-1:200
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Product Description specificalE3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.
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Gene nameWWP1
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locationCell membrane,Cytoplasm,Membrane,Nucleus
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Uniprot IDQ9H0M0
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Calculated M.W.95kDa
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Observed M.W.95 kDa
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