anti-VHL antibody

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  • Alternative name

    HRCA1, Protein G7, pVHL, RCA1, VHL, VHL1, Von Hippe-Lindau antibody

  • Catalog
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman,Mouse ,Rat
  • Applications Tested/SuitableELISA,IF,IHC
  • PurificationImmunogen affinity purified
  • Immunogenvon Hippel-Lindau tumor suppressor
  • IHCImmunohistochemical of paraffin-embedded human kidney using A009402(VHL antibody) at dilution of 1:50 
  • Recommended dilutionIF:1:10-1:100;IHC:1:20-1:200
  • Product Description specificalInvolved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.
  • Gene nameVHL
  • locationCytoplasm,Membrane,Nucleus
  • Uniprot IDP40337
  • Calculated M.W.20kDa

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