anti-USP15 antibody

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  • Alternative name

    Deubiquitinating enzyme 15, KIAA0529, Ubiquitin thiolesterase 15, Unph 2, UNPH4, USP15 antibody

  • Catalog
    A009311
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman,Mouse ,Rat
  • Applications Tested/SuitableELISA,WB,IP
  • PurificationImmunogen affinity purified
  • Immunogenubiquitin specific peptidase 15
  • IHCImmunohistochemistry of paraffin-embedded human breast cancer tissue slide using A009311( USP15 Antibody) at dilution of 1:200
  • Western Blotmouse brain tissue were subjected to SDS PAGE followed by western blot with A009311( USP15 Antibody) at dilution of 1:1000
  • Recommended dilutionWB : 1:500-1:5000;IP:1:500-1:5000;IHC:1:50-1:500
  • Product Description specificalHydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes (PubMed:21947082). According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal (PubMed:22344298). Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B (PubMed:24526689). Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway.
  • Gene nameUSP15
  • locationCytoplasm,Nucleus
  • Uniprot IDQ9Y4E8
  • Calculated M.W.112kDa
  • Observed M.W.112 kDa




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