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Alternative name
Deubiquitinating enzyme 11, Ubiquitin thiolesterase 11, UHX1, USP11 antibody
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Catalog
A009305
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB,IHC,IP,IF
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PurificationImmunogen affinity purified
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Immunogenubiquitin specific peptidase 11
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IHCImmunohistochemistry of paraffin-embedded human hepatocirrhosis tissue slide using A009305( USP11 Antibody) at dilution of 1:50
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Western BlotA549 cells were subjected to SDS PAGE followed by western blot with A009305(USP11 antibody) at dilution of 1:1000
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Recommended dilutionWB : 1:500-1:5000;IHC:1:20-1:200;IP:1:1000-1:10000;IF:1:20-1:200
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Product Description specificalProtease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'- linked ubiquitin chains (in vitro) (PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726).
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Gene nameUSP11
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locationCytoplasm,Nucleus
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Uniprot IDP51784
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Calculated M.W.110kDa
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Observed M.W.110 kDa
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