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Alternative name
URM1, C9orf74 antibody
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Catalog
A009289
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenubiquitin related modifier 1 homolog (S. cerevisiae)
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IHCImmunohistochemistry of paraffin-embedded human hepatocirrhosis using A009289(URM1 antibody) at dilution of 1:100
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Western Blothuman placenta tissue were subjected to SDS PAGE followed by western blot with A009289(URM1 antibody) at dilution of 1:1000
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Recommended dilutionWB : 1:500-1:5000;IHC：1:20-1:200
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Product Description specificalActs as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
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Gene nameURM1
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locationCytoplasm
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Uniprot IDQ9BTM9
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Calculated M.W.11kDa
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Observed M.W.11kd
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