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Alternative name
CD87, MO3, PLAUR, U PAR, UPAR, URKR antibody
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Catalog
A009268
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IP
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PurificationImmunogen affinity purified
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Immunogenplasminogen activator, urokinase receptor
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Western BlotRAW264.7 cells were subjected to SDS PAGE followed by western blot with A009268(uPAR, PLAUR antibody) at dilution of 1:500
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Recommended dilutionWB : 1:200-1:2000;IP：1:200-1:1000
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Product Description specificalUrokinase plasminogen activator surface receptor (uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. It contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, urokinase plasminogen activator (uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)
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Gene namePLAUR
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Uniprot IDQ03405
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Calculated M.W.37kDa,Observed 70kDa
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Observed M.W.35-70 kDa
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