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Alternative name
ATF, PLAU, U plasminogen activator, uPA, URK antibody
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Catalog
A009267
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IP,IF
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PurificationImmunogen affinity purified
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Immunogenplasminogen activator, urokinase
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IHCImmunohistochemistry of paraffin-embedded human skin using A009267(uPA antibody) at dilution of 1:50
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Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A009267(uPA antibody) at dilution of 1:500
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Recommended dilutionWB : 1:200-1:2000;IHC：1:20-1:200；IF:1：20-1：200;IP:1：500-1：5000
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Product Description specificalPLAU(Urokinase-type plasminogen activator) is also named as uPA and belongs to the peptidase S1 family.UPA initiates a proteolytic cascade, which degrades extracellular matrix during tissue growth and remodelling.The secreted proform of UPA is activated after binding to a specific high affinity cell surface receptor. Secreted UPA is exposed to rapid inactivation in the pericellular space by plasminogen activator inhibitor-1 (PAI-1), which is stored in the extracellular matrix bound to vitronectin(PMID:9665342).It has 2 isoforms produced by alternative splicing.Defects in PLAU are the cause of Quebec platelet disorder (QPD).
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Gene namePLAU
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locationSecreted
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Uniprot IDP00749
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Calculated M.W.50kDa
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Observed M.W.54 kDa
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