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Alternative name
BA49A4.1, C6orf133, dJ242G1.1, dJ392M17.3, DKFZp686C08114, KIAA0349, N recognin 2, RP3 392M17.3, UBR2 antibody
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Catalog
A009209
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IF,IHC
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PurificationImmunogen affinity purified
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Immunogenubiquitin protein ligase E3 component n-recognin 2
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IHCImmunohistochemistry of paraffin-embedded human pancreas tissue slide using A009209( UBR2 Antibody) at dilution of 1:50
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Western BlotBxPC-3 cells were subjected to SDS PAGE followed by western blot with A009209(UBR2 antibody) at dilution of 1:600
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Recommended dilutionWB : 1:200-1:2000;IF：1：10-1:100;IHC:1:20-1:200
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Product Description specificalE3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
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Gene nameUBR2
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locationNucleus
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Uniprot IDQ8IWV8
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Calculated M.W.66kDa
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Observed M.W.60-66 kDa
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