-
Alternative name
DA41, DSK2, FLJ90054, hPLIC 1, PLIC 1, PLIC1, ubiquilin 1, UBQLN1, XDRP1 antibody
-
Catalog
A009196
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman,Rat
-
Applications Tested/SuitableELISA,IHC,WB,IF
-
PurificationImmunogen affinity purified
-
Immunogenubiquilin 1
-
IHCImmunohistochemistry of paraffin-embedded human pancreas slide using A009196( UBQLN1 Antibody) at dilution of 1:50
-
Western Blotrat brain tissue were subjected to SDS PAGE followed by western blot with A009196( Ubiquilin 1 Antibody) at dilution of 1:300
-
Recommended dilutionWB : 1:200-1:1000;IF:1:10-1:100;IHC:1:20-1:200
-
Product Description specificalUBQLN1, also known as DSK2 or Ubiquilin 1, is an ubiquitin-like proteinis contains a?N-terminal?ubiquitin-like?domain?and a C-terminal ubiquitin-associated domain.?They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation.Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with?Alzheimer's?and?Parkinson's?disease. Two transcript variants encoding different isoforms have been found for this gene. Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease.Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP?(PMID: 21852239). This antibody detects 70kD band of UBQLN1.
-
Gene nameUBQLN1
-
locationCell membrane,Cytoplasm,Cytoplasmic vesicle,Endoplasmic reticulum,Membrane,Nucleus,Proteasome
-
Uniprot IDQ9UMX0
-
Calculated M.W.70kDa
-
Observed M.W.62-71 kDa
-