anti-UBE2K antibody

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  • Alternative name

    DKFZp564C1216, DKFZp686J24237, E2-25K, HIP 2, HIP2, HYPG, LIG, UBE2K, Ubiquitin carrier protein, Ubiquitin protein ligase antibody

  • Catalog
    A009178
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman,Mouse ,Rat
  • Applications Tested/SuitableELISA,WB,IHC
  • PurificationImmunogen affinity purified
  • Immunogenubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
  • IHCImmunohistochemistry of paraffin-embedded human gliomas using A009178(UBE2K antibody) at dilution of 1:50
  • Western Blothuman brain tissue were subjected to SDS PAGE followed by western blot with A009178(UBE2K antibody) at dilution of 1:400
  • Recommended dilutionWB : 1:500-1:5000;IHC:1:20-1:200
  • Product Description specificalAccepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein- dependent degradation of RB1.
  • Gene nameUBE2K
  • locationCytoplasm
  • Uniprot IDP61086
  • Calculated M.W.22kDa
  • Observed M.W.25 kDa


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