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Alternative name
FLJ54422, KIAA1474, Teashirt homolog 3, TSH3, TSHZ3, Zinc finger protein 537, ZNF537 antibody
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Catalog
A009046
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB
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PurificationImmunogen affinity purified
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Immunogenteashirt zinc finger homeobox 3
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Western Blotmouse brain tissue were subjected to SDS PAGE followed by western blot with A009046( TSHZ3 Antibody) at dilution of 1:600
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalTranscriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up- regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.
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Gene nameTSHZ3
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Uniprot IDQ63HK5
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Calculated M.W.110kDa
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Observed M.W.105-120 kDa
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