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Alternative name
LTrpC 5, LTRPC5, MTR1, TRPM5 antibody
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Catalog
A009021
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IF
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PurificationImmunogen affinity purified
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Immunogentransient receptor potential cation channel, subfamily M, member 5
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Western Blotmouse colon tissue were subjected to SDS PAGE followed by western blot with A009021(TRPM5 antibody) at dilution of 1:1000
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Recommended dilutionWB:1:500-1:5000;IP:1:200-1:1000;IF:N/A
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Product Description specificalVoltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5- triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage- dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.
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Gene nameTRPM5
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Uniprot IDQ9NZQ8
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Calculated M.W.98kDa,Observed 98kDa,80kDa
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Observed M.W.98 kDa
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