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Alternative name
C1orf8 antibody
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Catalog
A008787
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,IHC,WB,IF
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PurificationImmunogen affinity purified
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Immunogentransmembrane protein 59
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IHCImmunohistochemistry of paraffin-embedded human breast cancer slide using A008787( TMEM59 Antibody) at dilution of 1:50
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Western BlotMCF-7 cells were subjected to SDS PAGE followed by western blot with A008787( TMEM59 Antibody) at dilution of 1:300
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Recommended dilutionWB : 1:200-1:1000
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Product Description specificalActs as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
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Gene nameTMEM59
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Uniprot IDQ9BXS4
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Observed M.W.41 kDa
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