StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
Species ReactivityHuman, Mouse
PurificationImmunogen affinity purified
Immunogentranscription factor A, mitochondrial
IHCImmunohistochemistry of paraffin-embedded human kidney slide using A008614( TFAM Antibody) at dilution of 1:50
Western BlotHEK-293 cells were subjected to SDS PAGE followed by western blot with A008614(TFAM antibody) at dilution of 1:1000
Recommended dilutionWB : 1:500-1:5000
Product Description specificalBinds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.