anti-TAP1 antibody

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  • Alternative name

    ABCB2, PSF1, RING4, Y3 antibody

  • Catalog
    A008499
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman,Mouse ,Rat
  • Applications Tested/SuitableELISA,IF,WB,IHC,IP
  • PurificationImmunogen affinity purified
  • Immunogentransporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
  • IHCImmunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using A008499( TAP1 Antibody) at dilution of 1:50
  • Western BlotHepG2 cells were subjected to SDS PAGE followed by western blot with A008499( TAP1 Antibody) at dilution of 1:1000
  • Recommended dilutionWB : 1:500-1:5000
  • Product Description specificalInvolved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.
  • Gene nameTAP1
  • Uniprot IDQ03518
  • Observed M.W.70-81 kDa


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