anti-STAT3 antibody

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  • Alternative name

    APRF antibody

  • Catalog
    A008299
  • Size100μg
  • Formliquid
  • Purity≥95% as determined by SDS-PAGE
  • StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
  • ClonalityPolyclonal Antibody
  • Host Rabbit
  • Species ReactivityHuman, Mouse
  • Applications Tested/SuitableELISA,WB,IHC,IP
  • PurificationImmunogen affinity purified
  • Immunogensignal transducer and activator of transcription 3 (acute-phase response factor)
  • IHCImmunohistochemistry of paraffin-embedded human cervical cancer using A008299(STAT3 antibody) at dilution of 1:100
  • Western BlotK-562 cells were subjected to SDS PAGE followed by western blot with A008299(STAT3 antibody) at dilution of 1:500
  • Recommended dilutionWB : 1:200-1:2000
  • Product Description specificalSignal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity.
  • Gene nameSTAT3
  • Uniprot IDP40763
  • Observed M.W.88 kDa




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